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Doxycycline is a medication that is used to treat bacterial infections, and it's also prescribed as an acne treatment. It belongs to a group of medications called tetracyclines. When used as a treatment for depression, doxycycline helps fight the symptoms of depression because it alters serotonin levels in the brain by affecting how your body absorbs this chemical.
It can take some time for you to start feeling better after starting doxycycline therapy for depression.